aMCI and Alzheimer’s Dementia

Learn more about aMCI, the symptomatic, pre-dementia stage of Alzheimer’s.

Nearly every minute, someone in America transitions from normal aging when they occasionally experience senior moments of memory loss to a stage at which their memory loss becomes an everyday part of their life.

This stage is called aMCI, a transition disease state between a normal aging brain and Alzheimer’s dementia. There is no treatment for aMCI. For most, aMCI will progress within a few years to Alzheimer’s dementia.

You are Not Alone in Facing this Challenge

Today 5.2 million Americans and 25 million people worldwide suffer from aMCI, and this population will double by 2030.

Data from the National Institute on Aging show that modest delays have massive benefits to patients, their families, and society as a whole. For every year that the onset of Alzheimer’s dementia can be delayed,  there is an approximately 10% reduction in the prevalence of this disease.


Learn More about our HOPE4MCI Phase 3 clinical trial

To Learn More about aMCI and Alzheimer’s Dementia

Alzheimer’s Association

Alzheimer’s Foundation of America

Alzheimer’s Drug Discovery Foundation

National Institute on Aging

Administration on Aging

Alzheimer’s Disease Educational and Referral Center


1. Y Turana, T Ranakusuma, et al. “Enhancing Diagnostic Accuracy of aMCI in the Elderly: Combination of Olfactory Test, Pupillary Response Test, BDNF Plasma Level, and APOE Genotype,” Int J of Alzheimer’s Disease 2014. Available at: Accessed November 2014.