About MCI and Alzheimer’s Dementia

aMCI, the symptomatic, pre-dementia phase of Alzheimer’s, results from hippocampal overactivity.

Nearly every minute, someone in America transitions from normal aging when they occasionally experience senior moments of memory loss to a stage at which their memory loss becomes an everyday part of their life.

This stage is called aMCI, the symptomatic, pre-dementia stage of Alzheimer’s. There is no treatment for aMCI. For most, aMCI will progress within a few years to Alzheimer’s dementia.1


Decades of research show that best way to prevent and delay the progression to Alzheimer’s dementia is to intervene as early as possible, at the stage of aMCI. AGB101 is based on research showing that people with memory loss and increased risk for progressing to Alzheimer’s dementia have a condition of excess neuronal activity (hyperactivity) in a critical area of the brain responsible for creating new memories, the hippocampus.

Prevalence and Cost

Today 5.6 million Americans and 25 million people globally suffer from aMCI, and this population will double by 2030. By age 85, one of every three people will have Alzheimer’s disease. Alzheimer’s disease currently costs Medicare and Medicaid $150 billion in direct medical costs with the annual cost expected to exceed $1 trillion by 2050.

Data from the National Institute on Aging show that modest delays have massive benefits to patients, their families, and society as a whole. For every year delay in the onset of Alzheimer’s dementia, there is an approximately 10% reduction in the prevalence of this disease.

aMCI and Alzheimer’s dementia patient resources

K. Schmidtke, S Hermeneit. “High rate of conversion to Alzheimer’s disease in a cohort of amnestic MCI patients,” International Psychogeriatrics. 2008;20(1):96-108.