Pipeline

Our novel pipeline of therapies for neurological and psychiatric disease is based on decades of research focused on cognitive neuroscience and the neurobiology of the aging brain.

Research at Johns Hopkins and leading research centers around the world have demonstrated that overactivity in key brain circuits contributes to cognitive impairment and drives neurodegeneration if not controlled.

This overactivity is a characteristic feature of mild cognitive impairment due to Alzheimer’s disease (MCI due to AD), the earliest symptomatic stage characterized by memory loss. Overactivity detected by brain imaging predicts the extent of neurodegeneration in the earliest stages of MCI due to AD and clinical progression to dementia.

Our most advanced clinical program targets MCI due to AD. We are evaluating AGB101 for the treatment of hippocampal overactivity and slowing the progression and delay in onset of Alzheimer’s dementia.

AGB101

Our lead asset, currently in Phase 3 testing, is being evaluated for the treatment of MCI due to AD and delay progression to Alzheimer’s dementia.

Discovery: GABAA α5 positive allosteric modulators

Our novel late-stage discovery program is evaluating a spectrum of conditions including MCI due to AD, autism and schizophrenia.

These investigational compounds are not approved by the FDA. The safety and efficacy have not been established.